CyberKnife vs Gamma Knife

Gamma Knife and CyberKnife are similar in that they are both clinically proven systems for delivering high-dose radiation to tumors with sub-millimeter precision. However, that’s where the similarities end. CyberKnife has evolved from the conventional technology of the Gamma Knife to improve patient comfort during and after treatment and expand the parts of the body that can be treated. CyberKnife can perform dedicated stereotactic radiosurgery (SRS), just as Gamma Knife does, but it is also capable of delivering stereotactic body radiation therapy (SBRT), also called stereotactic ablative radiotherapy (SABR), which enables it to perform treatments throughout the body – not just the brain and cervical spine.


SRS is used by both systems to treat brain tumors, vascular lesions, and functional disorders such as acoustic neuroma, trigeminal neuralgia, and arteriovenous malformations (AVM). SRS is typically used as a primary treatment of operable, inoperable, or recurrent brain tumors. But it also can be used in combination with surgery, chemotherapy, and other treatments. Despite the fact that Gamma Knife and CyberKnife can both deliver SRS, there are key differences.


The Key Differences between CyberKnife S7 & Gamma Knife



Patient wears a soft, mesh mask during treatment


Patient wears a large, metal head frame that is bolted into the skull

Sub-millimeter accuracy, enabled by enhanced tumor tracking technology and real-time imaging Sub-millimeter accuracy, based on keeping the patient immobilized during treatment
Flexible treatment options, a single high dose treatment, or two to five lower dose treatments, generally completed within a week Due to the invasive head frame, patients are limited to one, high-dose treatment from fixed angles
Uses electrically generated photons to treat Uses radioactive cobalt to treat
Anesthesia is not needed Local anesthesia is often used
Treats tumors throughout the body Limited to tumor treatment in the skull and select cases in the cervical spine
First used in U.S. in 2001. First used in U.S. in 1979.


Another difference between the two systems is the method of radiation delivery. Gamma Knife is limited in the number of angles it can approach the tumor, while CyberKnife can deliver radiation from thousands of angles, limiting the impact of radiation on healthy tissue or organs surrounding the tumor.


The CyberKnife Advantage

While both Gamma Knife and CyberKnife can treat cancerous and non-cancerous tumors with extreme precision, CyberKnife offers unique advantages, particularly its ability to treat tumors throughout the entire body. With advanced robotics, intelligent tumor tracking, and real-time imaging capabilities, CyberKnife can treat tumors in the body that move as a result of breathing with the same precision as treatments to the brain, without requiring uncomfortable motion-restricting devices.


CyberKnife’s revolutionary advancements enable treatment of tumors in the brain, head and neck, spine, lung, prostate, liver, pancreas, kidney and more. CyberKnife’s precision and freedom from invasive head and body frames have opened the realm of treatments to recurrent tumors that were once thought untreatable after previous radiation or surgery.